fMLP作为第一个被发现的白细胞趋性肽 ,能迅速激活吞噬细胞 ,发挥强大的趋化活性。FPR ,FPRL1和FPRL2是迄今发现的仅有的三个fMLP的体内受体。除了FPRL2 ,另两种受体所拥有的体内外配体却远远不止fMLP。它们通过与不同的配体相互作用 ,参与机体的天然免疫、炎症反应 ,并通过与一些来源于HIV 1表面蛋白的人工肽相互结合 ,下调细胞表面其它趋化性受体的表达 ,产生“失敏反应”。 As the first leukotriene peptide to be found, fMLP rapidly activates phagocytes and exerts powerful chemotactic activity. FPR, FPRL1 and FPRL2 are by far the only three receptors for fMLP in vivo. In addition to FPRL2, the other two receptors possess far more than fMLP in vivo and in vitro ligands. They interact with different ligands to participate in the body’s natural immune response and inflammatory response, and by binding to some artificial peptides derived from HIV 1 surface protein, down-regulate the expression of other chemotactic receptors on the cell surface, resulting in “loss Sensitive reaction. ”