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肾上腺皮质激素已被公认为是治疗肾病综合征(NS)的有效药物,但在临床应用中,有部分患者对激素不敏感或减量后复发。环孢素A(CSA)联合雷公藤多甙(T_(?))治疗难治性NS,可使部分患者获得治愈或缓解。 1 临床资料 1.1 一般资料 Q5例患者随机分为A、B、C三组。A组33例,其中男23例,女10例,年龄13～51岁,平均31岁;B组31例,其中男20例,女11例,年龄14～49岁,平均30岁;C组31例,其中男22例,女9例,年龄13～48岁,平均31.5岁。A组为治疗组,B、C两组为对照组。三组病理类型见表1。经统计学处理三组性别、年龄、病理类型无差异。全部患者符合原发性NS诊断标准,即大量蛋白尿(尿蛋白>3.5g/d),低蛋白血症(血白蛋白<30g/L);且患者经过激素及细胞毒类药物治疗无效,或完全缓解后在1年内至少2次复发。
Corticosteroids have long been recognized as effective drugs in the treatment of nephrotic syndrome (NS). However, in clinical practice, some patients are hormone insensitive or relapse after reduction. Cyclosporine A (CSA) combined with tripterygium glycosides (T_ (?)) Treatment of refractory NS, some patients can be cured or alleviated. 1 Clinical data 1.1 General Information Q5 patients were randomly divided into A, B, C three groups. A group of 33 patients, including 23 males and 10 females, aged 13 to 51 years old, with an average of 31 years old; B group of 31 cases, 20 males and 11 females, aged 14 to 49 years, mean 30 years; C group 31 cases, including 22 males and 9 females, aged 13 to 48 years, an average of 31.5 years old. Group A as treatment group, B, C two groups as control group. Three types of pathology in Table 1. Three groups by statistical analysis of sex, age, pathological type no difference. All patients met the criteria of primary NS diagnosis: massive proteinuria (urinary protein> 3.5g / d), hypoproteinemia (serum albumin <30g / L); and patients treated with hormone and cytotoxic drugs were ineffective, Or complete remission within 1 year at least 2 times recurrence.