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目的:探讨儿童过敏性紫癜合并神经系统损害的临床表现、炎症因子检测与预后情况。方法:选择2008年2月～2012年4月我院收治的100例过敏性紫癜儿童,其中合并有神经系统损害儿童8例,对临床资料进行分析。结果:合并患儿临床主要表现为发热、皮疹、神经受累、痉挛等,其TPO与TGF-β检测值都明显高于非神经系统损害儿童(P<0.05)。8例都治疗成功,治疗成功率为100.0%。结论:儿童过敏性紫癜合并神经系统损害发病率相对少,但是临床表现危急,可能是由于细胞因子表达紊乱引起,及时治疗意义重大。
Objective: To investigate the clinical manifestations of children with Henoch-Schonlein Purpura with neurological damage, the detection and prognosis of inflammatory factors. Methods: From January 2008 to April 2012, 100 children with Henoch-Schonlein purpura were enrolled in our hospital, including 8 children with neurological damage and the clinical data were analyzed. Results: The clinical manifestations of the patients were fever, rash, nerve involvement and spasm. The detection values of TPO and TGF-β were significantly higher than those of non-nervous system children (P <0.05). 8 cases were successfully treated, the success rate was 100.0%. Conclusion: The incidence of Henoch-Schonlein purpura in children with nervous system damage is relatively small, but the clinical manifestations are critical, which may be caused by the disorder of cytokine expression.