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目的:观察曲藻降脂胶囊对实验性高脂血症大鼠的降脂作用。方法:用高脂饲料制作大鼠高脂血症模型。造模同时开始给药,每天给药1次,连续给药11周。观察药物对血液流变学、血脂和机体抗氧化系统的影响。结果:给药组的全血黏度(低切、中切),血浆黏度和血球容积都明显下降;血清TG、TC、LDL-C均有不同程度的降低,HDL-C明显升高;血清和肝匀浆中的SOD升高,MDA降低;肝细胞的脂肪变性明显减轻。结论:曲藻降脂胶囊对大鼠的实验性高脂血症有明显的降脂作用,并提高机体的抗氧化损伤能力,促进血流变指标的改善,阻止肝脏的脂肪变性。
Objective: To observe the lipid-lowering effect of “Qiaozao Jiangzhi Capsule” on experimental hyperlipidemic rats. METHODS: Rat hyperlipidemia model was made with high-fat diet. At the same time, the model was started to be administered, once a day, and continuously for 11 weeks. Observe the effects of drugs on hemorheology, blood lipids, and the body’s antioxidant system. RESULTS: The whole blood viscosity (low cut, middle cut), plasma viscosity and hematocrit volume were significantly decreased in the treated group; serum TG, TC, and LDL-C all decreased to varying degrees, and HDL-C increased significantly; serum and SOD in the liver homogenate increased, MDA decreased; steatosis of liver cells was significantly reduced. Conclusion: Chuzao Jiangzhi capsule has significant lipid-lowering effect on experimental hyperlipidemia in rats, and improves the body’s ability of anti-oxidative damage, promotes the improvement of blood rheological parameters, and prevents hepatic steatosis.