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目的测定和评估足月新生儿行为神经能力并探讨其影响因素,为早期发现新生儿大脑发育异常和早期干预提供科学依据。方法采用新生儿20项行为神经评分测定(neonatal behavior neurological assessment,NBNA)量表对2010年12月至2013年5月在甘肃省民乐县妇幼保健院分娩的单胎足月新生儿3 035例,在出生后3 d进行行为神经能力测定和评估,分析新生儿行为神经测评评分的影响因素。结果 NBNA异常率(评分≤35分)足月单胎新生儿为19.67%,足月低出生体重儿为75.53%。多因素Logistic回归分析发现,低出生体重(OR=17.39,95%CI:10.36~29.20)和较大孕周(OR=1.12,95%CI:1.02~1.23)可增加NBNA异常风险,而母亲具有大学以上文化程度使风险降低(OR=0.41,95%CI:0.21~0.81)。结论低出生体重是引起单胎足月新生儿NBNA异常的重要因素,而母亲文化程度高将减少NBNA异常率。
Objective To determine and assess the behavioral neurobehavioral changes of full-term newborn infants and to explore the influencing factors, providing a scientific basis for the early detection of neonatal cerebral dysplasia and early intervention. Methods A total of 3035 singletonic full-term newborns were delivered in Minle Maternal and Child Health Care Hospital of Gansu Province from December 2010 to May 2013 with neonatal behavior neurological assessment (NBNA) Behavioral neuroimaging and assessment were performed 3 days after birth to analyze the influencing factors of neonatal behavioral neuroimaging scores. Results Abnormal rate of NBNA (score≤35 points) was 19.67% for full-term singleton newborn and 75.53% for full-term low birth weight. Multivariate logistic regression analysis showed that the abnormalities of NBNA increased with low birth weight (OR = 17.39,95% CI 10.36-29.20) and larger gestational age (OR = 1.12,95% CI: 1.02-1.23) The degree of education at or above the university reduced the risk (OR = 0.41, 95% CI: 0.21-0.81). Conclusions Low birth weight is an important factor that causes NBNA abnormalities in singleton full-term newborns. High mother’s education level will reduce the abnormal rate of NBNA.