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目的:探讨高原地区重叠综合征(OS)患者的部分肺功能指标、血氧饱和度的变化及临床意义,比较分析与单纯性阻塞性睡眠呼吸暂停低通气综合征(OSAHS)或慢性阻塞性肺疾病(COPD)患者的差别关系。方法:利用多导睡眠监测和肺功能检测记录3组患者的睡眠呼吸暂停低通气指数(AHI)、夜间睡眠时最低血氧饱和度(SaO2)、静息状态下的用力肺活量(FVC),第一秒用力呼气容积(FEV1)指标,经统计分析比较其差异。结果:OS组体重指数显著高于OSAHS组和COPD组患者,且OSAHS组体重指数显著高于COPD组(P<0.05);OS组和OSAHS组AHI显著高于COPD组,而SaO2显著低于COPD组,OS组和OSAHS组之间AHI和SaO2也存在显著性差异;COPD组和OS组FEV1预计值百分比以及FEV1/FVC(%)均显著低于OSAHS组,且OS组显著低于COPD组。结论:高原地区OS患者在COPD和OSAHS患者中的发病率均较高,且高原地区寒冷低气压的气候条件会进一步加重OS患者夜间的低氧状态,对于本地区的COPD或OSAHS患者均需通过多导睡眠监测(PSG)或肺功能检测明确是否为OS患者,一旦确诊,必须给予足够的重视。
Objective: To investigate the changes and clinical significance of some pulmonary function indexes, oxygen saturation in patients with overlap syndrome (OS) in the plateau area. To compare and analyze the changes and clinical significance of OSAHS or chronic obstructive pulmonary Differences between patients with disease (COPD). Methods: The sleep apnea-hypopnea index (AHI), night-time sleep oxygen saturation (SaO2), resting vital capacity (FVC) were recorded by using polysomnography and pulmonary function test. One second forced expiratory volume (FEV1) indicators, the statistical analysis to compare the differences. Results: The body mass index in OS group was significantly higher than that in OSAHS group and COPD group, and the body mass index in OSAHS group was significantly higher than that in COPD group (P <0.05); AHI in OS group and OSAHS group was significantly higher than that in COPD group, while SaO2 was significantly lower than that in COPD group There were also significant differences in AHI and SaO2 between OSAHS group and OSAHS group. The predicted FEV1 percentage and FEV1 / FVC (%) in COPD group and OS group were significantly lower than those in OSAHS group and OS group was significantly lower than that in COPD group. CONCLUSIONS: The prevalence of OS in high altitude patients in both COPD and OSAHS is high, and the cold and baric climatic conditions in the plateau further aggravate the nocturnal hypoxia in OS patients, both for patients with COPD or OSAHS in this region Polysomnography (PSG) or pulmonary function tests are clearly OS patients, once diagnosed, we must pay enough attention.