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目的探讨吸入不同剂量布地奈德对治疗咳嗽变异型哮喘临床疗效的影响。方法 126例于我院就诊并接受治疗的咳嗽变异型哮喘患者纳入本研究,随机均分为试验组和对照组,试验组接受吸入小剂量布地奈德,对照组则大剂量吸入布地奈德;治疗结束时对比两组患者的临床疗效和不良反应、第一秒用力呼气容积占预计值的百分比、最大呼气流速、嗜酸性粒细胞百分数和咳嗽症状评分。结果两组患者治疗后临床疗效和不良反应发生率并无差异(P>0.05),但第一秒用力呼气容积占预计值的百分比、最大呼气流速、嗜酸性粒细胞百分数和咳嗽症状评分试验组均明显优于对照组(P<0.05)。结论大剂量布地奈德雾化吸入与小剂量雾化吸入治疗临床疗效和不良反应相似,但大剂量更能有效改善患者肺功能和炎症反应,临床应首先考虑应用。
Objective To investigate the effects of different doses of budesonide on the clinical efficacy of cough variant asthma. Methods A total of 126 cough variant asthma patients treated and treated in our hospital were enrolled in this study and were randomly divided into experimental group and control group. Small amount of budesonide was inhaled in the test group and budesonide was inhaled in the control group. At the end of treatment, the clinical efficacy and adverse reactions were compared between the two groups, with the predicted forced expiratory volume in the first second as a percentage of the predicted value, the maximum expiratory flow rate, the percentage of eosinophils, and the cough symptom score. Results There was no difference in clinical efficacy and incidence of adverse reactions between the two groups (P> 0.05), but the first second forced expiratory volume as a percentage of predicted value, the maximum expiratory flow rate, eosinophil percentage and cough symptom score The experimental group were significantly better than the control group (P <0.05). Conclusion High-dose budesonide inhalation and low-dose nebulized inhalation are similar in clinical efficacy and adverse reactions. However, high-dose budesonide can effectively improve pulmonary function and inflammatory response. Clinical application should be considered first.