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目的探讨bFGF在IgA肾病肾小管间质病变中的检验价值。方法选取2009年12月——2010年12月本院收治的肾活检确诊IgA肾病肾小管间质病变患者45例设为观察组,选取同期来本院进行肾肿瘤切除患者45例的正常肾组织设为对照组,全部进行bFGF检查,比较检查结果。结果观察组肾间质肾小管bFGF阳性面积比值为0.29±0.12,对照组肾间质肾小管bFGF阳性面积比值为0.04±0.03。两组间的肾小管bFGF阳性面积比值具有显著性差异,(t=12.1231,P<0.05),有统计学意义。结论 bFGF和IgA肾病肾小管间质病变具有密切的关系,在IgA肾病肾小管间质病变临床诊断上具有重要意义。
Objective To investigate the diagnostic value of bFGF in tubulointerstitial lesions of IgA nephropathy. Methods Forty-five patients with renal tubulointerstitial lesions confirmed by renal biopsy in our hospital from December 2009 to December 2010 were selected as the observation group. Forty-five normal renal tissues were selected from our hospital for renal tumor resection in the same period. As a control group, all bFGF examination, comparison test results. Results The positive area ratio of bFGF in tubule of renal interstitium in observation group was 0.29 ± 0.12, and the positive area ratio of bFGF in renal tubule in control group was 0.04 ± 0.03. There was a significant difference in the ratio of bFGF positive area between the two groups (t = 12.1231, P <0.05), with statistical significance. Conclusions bFGF and IgA nephropathy have a close relationship with tubulointerstitial lesions, which is of great importance in the clinical diagnosis of tubulointerstitial lesions of IgA nephropathy.