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目的观察光动力疗法治疗进展期食管癌的疗效和安全性。方法18例不愿意手术或失去手术机会的进展期食管癌患者,行内镜下光动力联合化疗治疗;于治疗前及治疗后1、2、3、6、9和12个月复查内镜并进行临床症状评定,随访生存时间,观察毒副作用。结果18例患者平均随访时间6.7个月(0.5～19.0个月);临床症状缓解率77.8%(14/18);内镜下完全应答率16.7%(3/18),部分应答率为38.9%(7/18);半年生存率55.6%(10/18),1年生存率22.2%(4/18);中位生存期为7个月。1例患者术后1周出现大出血,并发症发生率为5.6%(1/18);未见光过敏等副反应发生。结论光动力疗法可显著改善食管癌患者的临床症状,是治疗进展期食管癌又一有效手段。
Objective To observe the efficacy and safety of photodynamic therapy for advanced esophageal cancer. Methods Eighteen patients with advanced esophageal cancer who did not want surgery or surgery loss underwent endoscopic photodynamic therapy combined with chemotherapy. The endoscopy was performed before treatment and at 1, 2, 3, 6, 9 and 12 months after treatment Clinical symptom assessment, follow-up survival time, observe the toxic side effects. Results The average follow-up time was 6.7 months (0.5-19.0 months) in 18 patients. The rate of clinical symptom relief was 77.8% (14/18). The complete response rate was 16.7% (3/18) and the partial response rate was 38.9% (7/18). The half-year survival rate was 55.6% (10/18) and the one-year survival rate was 22.2% (4/18). The median survival time was 7 months. One patient developed major hemorrhage one week after operation, with a complication rate of 5.6% (1/18); no side effects such as photosensitivity occurred. Conclusion PDT can significantly improve the clinical symptoms of patients with esophageal cancer is another effective treatment for advanced esophageal cancer.