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为探讨肺结核病用药与耐药的相关性，对１９９０年全省流行病学抽样调查查出的７０例痰抗酸菌培养阳性病例进行用药与耐药情况分析。耐药标准采用全国统一标准。试验药物为：异烟肼（Ｈ）、利福平（Ｒ）、链霉素（Ｓ）、乙胺丁醒（Ｅ）、对氨基水扬酸钠（Ｐ）、氨硫脲（Ｔ）这６种主要的抗痨药物。结果显示：６种药物的起始耐药之间无差异，继发耐药明显高于起始耐药，ＳＨ最高、ＲＥ最低；三种及三种以上药物联合且至少连续规则使用２个月者，未发现继发耐药病例，基它情况的继发耐药率均超过５０％；ＳＨ的继发耐药中５０％是间断药用达２个月的病例。结论：对曾经三种及三种以上联合用药且连续用药达２个月的病例，在重新治疗制订化疗方案时可不考虑耐药问题，其他情况必须慎重选药，尤其是ＳＨ曾经间断用药达２个月的病例，应考虑继发耐药。
In order to explore the correlation between drug use and drug resistance in tuberculosis, 70 drug-resistant and resistant cases of sputum acid-fast bacilli culture-positive cases detected by epidemiological sampling survey across the province in 1990 were analyzed. Drug resistance standards using the national standard. The test drugs were: isoniazid (H), rifampicin (R), streptomycin (S), ethambutamide (E), sodium p-aminosalicylate (P) Six major anti-tuberculosis drugs. The results showed that there was no difference between the initial drug resistance of the six drugs, the secondary drug resistance was significantly higher than the initial drug resistance, SH highest, RE lowest; three and more than three drugs combined and at least continuous use of 2 months , No case of secondary resistance was found, the secondary case-resistant rates were more than 50%; 50% of SH secondary drug-resistant cases were discontinued for up to 2 months. CONCLUSIONS: For patients who have been treated with three or more drugs in combination for two consecutive months, drug resistance may not be considered in the re-treatment of the chemotherapy regimen. Drugs must be carefully selected in other cases. In particular, SH was discontinued twice a day Months of cases, should consider secondary resistance.