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8只5月龄雌性 SD 大鼠自由饮用80ppm 氟化钠水溶液18周后,改饮80ppm 氟化钠水溶液+20%酒精(F+A 组)。用体视学方法计量了该组大鼠和6只单纯饮用80ppm 氟化钠水溶液大鼠(F 组)、7只单纯饮用20%酒精大鼠(A 组),6只仅饮用去离子水大鼠(C 组)的以下改变:1.肝细胞核的体密度、面密度,肝细胞的核质比和肝细胞的平均直径。2.肝细胞线粒体的体密度、面密度、面数密度和规化形状因子。计量结果表明,与单纯氟化钠和单纯酒精对于大鼠肝细胞的损伤相比,在本实验条件下,在较长时间联合饮用氟化钠水溶液和酒精后,发现:1.更显著地引起大鼠肝细胞活跃增生。2.更显著地引起大鼠肝细胞线粒体的畸形和增生。提示:氟化钠和酒精对于大鼠肝细胞具有一定的联合毒性作用,高氟区人群,尤其是慢性氟中毒患者,对于酒精所致的肝细胞损伤可能具有更高的敏感性。
Eight 5-month-old female Sprague-Dawley rats were free to drink 80 ppm aqueous sodium fluoride for 18 weeks and then switched to 80 ppm sodium fluoride aqueous solution plus 20% alcohol (Group F + A). This group of rats and 6 rats (F group) were enrolled in this study by stereological method and 80% sodium fluoride aqueous solution (F group), and only 20% alcoholic rats (Group A) were simply drank with deionized water The following changes were observed in rats (group C): 1. Hepatocyte nuclear bulk density, areal density, hepatocyte nuclear mass ratio, and hepatocyte average diameter. 2. Hepatocyte mitochondrial body density, areal density, areal density and shape factor. The metrological results show that, compared with the injury of rat hepatocytes with pure sodium fluoride and pure alcohol, it was found that, in this experimental condition, after a long period of combined drinking of sodium fluoride aqueous solution and alcohol, 1. more pronounced Rat hepatocytes actively proliferate. 2. More significantly caused mitochondrial deformity and proliferation of rat hepatocytes. It is suggested that sodium fluoride and alcohol have certain combined toxic effects on rat hepatocytes. Patients with high fluoride area, especially those with chronic fluorosis, may have higher sensitivity to alcohol-induced hepatocyte injury.