论文部分内容阅读
目的探讨乳腺梭形细胞癌的病理组织学形态特征、诊断与鉴别诊断。方法复习2例乳腺梭形细胞癌的临床资料,观察其组织病理学表现,并进行免疫组化染色,同时回顾总结相关文献资料。结果 2例均为女性,年龄分别为46岁和60岁。肿瘤直径分别为2 cm和2.8 cm。2例肿瘤均由梭形细胞组成,其间可见少量上皮样细胞,其中例1细胞较丰富,细胞排列成束状;例2由温和的梭形细胞组成,间质有明显的玻璃样变,组织形态类似于纤维瘤病。肿瘤组织中的梭形细胞及上皮样细胞CK、CK5/6、34βE12和p63(+)。例1术后5个月复发。结论乳腺梭形细胞癌是乳腺的一种化生性癌,易误诊,诊断时需与纤维瘤病、叶状肿瘤和乳腺肉瘤等鉴别。梭形细胞癌预后不良,常常发生局部复发和远处转移,但低级别纤维瘤病样梭形细胞癌预后较好。
Objective To investigate the histopathological features, diagnosis and differential diagnosis of spindle cell carcinoma of the breast. Methods The clinical data of 2 cases of breast spindle cell carcinoma were reviewed. The histopathological features were observed and the immunohistochemical staining was performed. At the same time, the related literatures were reviewed. Results Both cases were female and were 46 years old and 60 years old respectively. Tumor diameter was 2 cm and 2.8 cm respectively. In both cases, the tumors consisted of spindle cells with a small number of epithelioid cells. Among them, the cells in case 1 were abundant and the cells arranged in bundles. Case 2 consisted of mild spindle cells with obvious glassy changes in the interstitium, Morphology is similar to fibromatosis. Fusiform cells and epithelioid cells CK, CK5 / 6, 34βE12 and p63 (+) in tumor tissue. Example 1 5 months after the recurrence. Conclusion Fusiform cell carcinoma of the breast is a metaplastic carcinoma of the breast, which is easily misdiagnosed and needs to be differentiated from fibromatosis, phyllodes tumor and breast sarcoma in the diagnosis. Fusiform cell carcinoma of the poor prognosis, local recurrence and distant metastasis often occur, but low grade fibromatosis like spindle cell carcinoma prognosis is good.