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Y盒结合蛋白1(YB-1)普遍存在于原核和真核生物细胞中,是一种DNA/RNA结合蛋白,结构上包含一个高度保守的冷休克结构域(cold shock domain,CSD),能够与目的基因启动子和增强子内部的Y-box序列(CTGAT TGG CCA A)特异性结合[1]。近年来,人们对YB-1蛋白在恶性肿瘤发生发展及预后中的研究越来越深入,已成为恶性肿瘤研究中的热点之一。研
Y cassette-binding protein 1 (YB-1), which is ubiquitous in prokaryotic and eukaryotic cells, is a DNA / RNA binding protein that structurally contains a highly conserved cold shock domain (CSD) And the target gene promoter and enhancer within the Y-box sequence (CTGAT TGG CCA A) specific binding [1]. In recent years, the research of YB-1 protein in the development and prognosis of malignant tumors has become more and more in depth, and has become one of the hot spots in the study of malignant tumors. research