将天然多元醇(蓖麻油)、聚乙二醇(PEG)和异佛尓酮二异氰酸酯通过缩聚反应制备了聚氨酯(PU)预聚物。在不添加乳化剂和助稳定剂的条件下,采用细乳化工艺得到稳定的PU细乳液。利用二乙烯三胺和异氰酸酯基团之间快速的交联反应进一步得到了PU微球。研究发现,乙酸乙酯和丙酮的配比影响微球的大小和形态,选择蓖麻油和PEG作为多元醇组分使微球具有了生物可降解性和亲水性。 Polyurethane (PU) prepolymers were prepared by polycondensation of natural polyols (castor oil), polyethylene glycol (PEG) and isophorone diisocyanate. In the absence of added emulsifier and costabilizer conditions, the use of miniemulsion process to obtain a stable PU miniemulsion. PU microspheres were further obtained by the rapid cross-linking reaction between diethylenetriamine and isocyanate groups. The results showed that the ratio of ethyl acetate to acetone affected the microsphere size and morphology. The castor oil and PEG were chosen as the components to make the microspheres biodegradable and hydrophilic.