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目的观察益气化瘀利水方对实验性兔膝骨关节炎组织形态学的影响。方法按Colombo法建立家兔膝骨关节炎模型,并随机分为空白组、模型组、中药组(益气化瘀利水方)和西药对照组。中药组和西药组均于术后第5周起治疗,各组于术后第9周取材,取股骨外髁进行光镜及透射电镜观察。结果中药组和西药组在关节软骨退变现象的程度方面较造模组轻。结论益气化瘀利水方能明显减缓骨关节炎的发生。
Objective To observe the effect of Yiqi Huayu Lishui Prescription on the histomorphology of experimental knee osteoarthritis in rabbits. Methods Rabbit knee osteoarthritis models were established according to the Colombo method and randomly divided into blank group, model group, Chinese medicine group (Yiqi Huayu Lishui Fang) and western medicine control group. The Chinese medicine group and the western medicine group were treated from the 5th week after operation. The groups were taken at the 9th week after operation and the outer femoral condyle was taken for light and transmission electron microscopy. Results The extent of articular cartilage degeneration in the Chinese medicine group and western medicine group was lighter than that of the model group. Conclusion Yiqi Huayu Lishui can significantly reduce the occurrence of osteoarthritis.