为了寻找早期检测肝功能改变的简易指标,作者对职业性接触低剂量甲苯和二甲苯工人的血清结合胆酸(一种较新的肝功能筛选指标)进行了研究。研究对象为一家造漆厂中的25名工人,平均年龄42.3岁,平均接触期10年,无肝病史,研究前几个月无服药史,接触甲苯、二甲苯、异丁基乙酸酯和甲基异丁基酮的时间加权平均浓度小于ACGIH规定阈限值的十分之一。另选25名未接触者为对照组。 In an effort to find a simple indicator of early detection of liver function changes, the authors studied serum bound bile acids (a newer marker of liver function screening) for occupational exposure to low-dose toluene and xylene workers. The study population consisted of 25 workers in a paint-making factory with an average age of 42.3 years and an average contact duration of 10 years without a history of liver disease. Non-medication history was observed in the first few months of the study. Exposure to toluene, xylene, isobutyl acetate and The time-weighted mean concentration of methyl isobutyl ketone is less than one-tenth of the ACGIH specified threshold limit. Another 25 non-contact as control group.