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为探讨尼莫地平对胰腺疾病患者血胰屏障通透性的影响，采用反相高压液相色谱法对１５例胰腺疾病患者在口服尼莫地平后不同时段胰液标本中的尼莫地平浓度进行了检测。结果：在用药后０．５、１、１．５、２、２．５、３、３．５和４小时，该１５例受试者胰液中的尼莫地平平均浓度分别为４．７９、７．３１、９．２１、８．０４、６．０５、５．１１、３．３７和１．１９ｎｇ／ｍｌ；尼莫地平的胰液浓度高峰时间为用药后１．５～２小时，最高浓度为９．２１ｎｇ／ｍｌ。由此提示尼莫地平可以穿透血胰屏障，这也是它在胰腺组织内发挥药理作用的生理基础
In order to explore the effect of nimodipine on the permeability of blood-pancreas barrier in patients with pancreatic diseases, the concentrations of nimodipine in pancreatic juice samples from 15 patients with pancreatic diseases at different time points after oral administration of nimodipine were determined by reversed-phase high-pressure liquid chromatography The test. Results: After 0.5, 1, 1.5, 2, 2.5, 3, 3.5 and 4 hours, the average nimodipine concentrations of pancreatic juice in these 15 subjects were 4.79, 7.31, and 1.19ng / ml respectively; the peak time of nimodipine pancreatic juice concentration was 1.5-2 hours after the administration, the highest concentration Was 9.21 ng / ml. This suggests that nimodipine can penetrate the blood-pancreas barrier, which is also the physiological basis for its pharmacological effects in pancreatic tissue