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目的:通过药效学实验比较连翘超临界CO2萃取物、分子蒸馏蒸出物和水提物的解热、镇痛效果。方法:用2,4-二硝基苯酚法比较萃取物、分离物及水提物的解热效果;腹腔注射醋酸溶液法比较萃取物、分离物及水提物的镇痛效果。结果:连翘水提物的解热、镇痛效果均优于超临界萃取物和分子蒸馏蒸出物。结论:连翘发挥解热和镇痛作用的主要有效成分存在于水溶性部分。
OBJECTIVE: To compare the antipyretic and analgesic effect of Forsythia suspensa supercritical CO2 extract, molecular distillation distillate and water extract through pharmacodynamic experiments. Methods: The antipyretic effects of extracts, isolates and water extracts were compared by 2,4-dinitrophenol method. The analgesic effects of extracts, isolates and water extracts were compared by intraperitoneal injection of acetic acid solution. Results: The antipyretic and analgesic effect of Forsythia suspensa extract was better than that of supercritical fluid extraction and molecular distillation. Conclusions: The main active ingredients of Forsythia suspensa which exert antipyretic and analgesic effects exist in the water-soluble fraction.