人类肉瘤根据其起源组织分成许多类型和亚型,制备肉瘤特异性抗原的单克隆抗体(MAbs)可提高诊断率并进行分类。但到目前为止所得到的抗体与其他肿瘤及正常组织有交叉反应,故用途受限。制备肉瘤相关抗原抗体的主要困难是本病很罕见,难以取得新鲜肉瘤组织。近来用无胸腺鼠使肉瘤生长以及体外单层肉瘤细胞培养取得成功,为肿瘤细胞提供了 Human sarcomas are divided into many types and subtypes based on their origin. Mabs specific antigen-producing monoclonal antibodies (MAbs) can improve the diagnostic rate and classify them. However, the antibodies obtained so far have cross-reactions with other tumors and normal tissues, so their use is limited. The main difficulty in preparing sarcoma-associated antigens is that the disease is rare and it is difficult to obtain fresh sarcoma tissue. Recently, the use of athymic mice for the growth of sarcomas and the successful cultivation of in vitro monolayer sarcoma cells have provided tumor cells with