【摘 要】
：
目的 探讨表皮生长因子受体(EGFR)、survivn和异质性胞核核糖蛋白A2和B1(hnRNPA2/B1)在肺癌纤维支气管镜刷片细胞学诊断中的价值.方法 收集纤维支气管镜刷片细胞学临床诊断剩
【机 构】
：
中国医学科学院北京协和医学院肿瘤医院病理科细胞学室
论文部分内容阅读
目的 探讨表皮生长因子受体(EGFR)、survivn和异质性胞核核糖蛋白A2和B1(hnRNPA2/B1)在肺癌纤维支气管镜刷片细胞学诊断中的价值.方法 收集纤维支气管镜刷片细胞学临床诊断剩余标本197例,免疫细胞化学两步法(Envision)染色,检测EGFR、survivn和hnRNPA2/B1在非小细胞肺癌(NSCLC)、小细胞肺癌(SCLC)及非肺癌组织中的表达情况.结果 EGFR、survivn和hnRNPA2/B1在NSCLC中表达率分别为81.1%、66.2%和90.9%,在非肺癌组织中的表达率分别为30.3%、3.3%和66.7%,差异均有统计学意义(均P＜0.05);hnRNPA2/B1在SCLC表达率为92.3%,与非肺癌组织比较,差异有统计学意义(P＜0.05).EGFR的表达与肿瘤分化程度、淋巴结转移和TNM分期有关(P＜0.05),hnRNP A2/B1表达与TNM分期有关(P＜0.05).NSCLC和非肺癌组织中,EGFR和survivn共同表达的差异有统计学意义(98.0%和2.0%,P=0.000),EGFR和survivn均不表达的差异亦有统计学意义(38.2%和61.8%,P=0.000).结论 EGFR、survin和hnRNPA2/B1在肺癌纤维支气管镜刷片细胞学诊断中有较高的敏感性和特异性.EGFR与survivn联合应用可以提高细胞学诊断的准确性.EGFR阳性表达与肺癌患者的预后有关.
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