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目的对京尼平(genipin)的结构进行改造以阐明其药效结构。方法以京尼平为原料,通过Swern反应和选择性还原反应合成目标化合物,其结构经现代波谱方法鉴定。结果与结论合成了3个京尼平衍生物,单步收率在77%~90%;3个化合物的结构均经1H-NMR1、3C-NMR和MS谱确证。
Objective To modify the structure of genipin to clarify its pharmacodynamic structure. Methods Genipin was used as the starting material to synthesize target compounds by Swern reaction and selective reduction reaction. The structure was identified by modern spectroscopy. RESULTS AND CONCLUSIONS Three derivatives of genipin were synthesized and the single-step yields ranged from 77% to 90%. The structures of the three compounds were confirmed by 1H-NMR1,3C-NMR and MS spectra.