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1例70岁男性患者因咳嗽、咯痰加重,伴发热、气促,给予头孢哌酮钠-舒巴坦钠、万古霉素、奥美拉唑、泼尼松、谷胱甘肽治疗。治疗第8天,因抑郁症给予西酞普兰10mg,1次/d。第9天丙氨酸转氨酶(ALT)及天冬氨酸转氨酶(AST)分别从47U/L、52U/L升至139U/L、145U/L。第10天因抑郁症状未控制,西酞普兰加量至20mg,1次/d。之后肝酶明显增高,第19天实验室检查示ALT529U/L,AST 256U/L。考虑为西酞普兰引起的肝功能异常,遂停用该药,其他合并用药继续应用。随后肝功能水平逐渐下降。
A 70-year-old male patient was treated with cefoperazone sodium-sulbactam sodium, vancomycin, omeprazole, prednisone, and glutathione due to increased cough, expectoration, fever, and shortness of breath. On day 8 of treatment, citalopram 10 mg was given once daily for depression. On day 9, ALT and AST increased from 47U / L and 52U / L to 139U / L and 145U / L, respectively. On the 10th day because of depressive symptoms uncontrolled, citalopram dosage to 20mg, 1 / d. Liver enzymes were significantly higher after the 19th day laboratory tests showed ALT529U / L, AST 256U / L. Considered as citalopram-induced liver dysfunction, then stop the drug, other combinations continue to be used. Subsequent decline in liver function levels.