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目的 :探讨聚合酶链反应 (PCR)对隐匿性鼻咽癌的诊断意义。方法 :采用 PCR检测 58例颈部肿块的细针抽吸标本中的 EB病毒 (EBV)。结果 :35例颈中、上淋巴结转移癌 2 8例 EBV阳性 ,3例淋巴瘤阴性 ,4例锁骨上淋巴结转移癌阴性 ;1 6例淋巴结炎性病变 1例为弱阳性 ,1 5例均为阴性 ;该法诊断鼻咽癌的灵敏度为 89.3% ,特异性为 86.7%。结论 :用 PCR检测颈部转移癌中的EBV- DNA,对隐匿性鼻咽癌的诊断具有一定的临床意义。
Objective: To investigate the significance of polymerase chain reaction (PCR) in the diagnosis of occult nasopharyngeal carcinoma. Methods: Epstein-Barr virus (EBV) was detected by PCR in 58 cases of fine needle aspiration of neck mass. Results: Twenty-eight cases of EBV were positive in the middle and upper cervical lymph nodes, 3 were negative for lymphoma and 4 were negative for supraclavicular lymph node metastasis. One of the 16 cases with lymph node inflammatory lesions was weakly positive, and all of the 15 cases were Negative; The sensitivity of nasopharyngeal carcinoma diagnosed by the method was 89.3% with a specificity of 86.7%. Conclusion: The detection of EBV-DNA in cervical metastatic carcinoma by PCR is of clinical significance for the diagnosis of occult nasopharyngeal carcinoma.