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【目的】探讨局部注射曲安奈德及卡介菌多糖核酸（BCG‐PSN ）治疗口腔扁平苔藓的可行性和安全性。【方法】选择口腔扁平苔藓患者268例，按数字随机法分为观察组（ n ＝134）和对照组（ n＝134）。观察组根据病理检查结果分为A组（糜烂型，n＝66）和B组（非糜烂型，n＝68）两个亚组，对照组则分为C组（糜烂型，n＝65）和D组（非糜烂型，n＝69）两个亚组。对照组在病损基底部注射曲安奈德40 mg和2％利多卡因2 mL治疗。观察组在对照组的基础上在病损基底部注射BCG‐PSN 1 mL治疗。统计分析两组疗效、治疗前后血清炎症因子水平、复发及不良反应发生情况。【结果】A组和B组疗效显效率和总有效率均高于C组和D组，差异均有统计学意义（均 P＜0．05）。A组和B组、C组和D组治疗效果比较差异均无统计学意义（均 P ＞0．05）。A组和B组、C组和D组治疗前后血清IL‐6和TNF‐α等炎症因子水平比较差异无统计学意义（ P ＞0．05）。与A组和B组比较，C组治疗1周、3周和6周的血清炎症因子水平均较高，D组同期血清炎症因子水平亦均较高（ P＜0．05）。A组治疗后1个月、3个月、6个月复发率均低于C组；B组治疗后1个月、3个月、6个月复发率均低于D组（ P ＜0．05）。【结论】局部注射曲安奈德及BCG‐PSN治疗口腔扁平苔藓疗效显著，可有效抗炎并预防术后复发，其对非糜烂型口腔扁平苔藓复发的预防效果更佳，且不增加不良反应，具有良好的可行性和安全性。“,”[Objective]To explore the therapeutic efficacy of local injection of triamcinolone acetonide injection ,BCG polysaccharideand nucleic acid injection for oral lichen planus .[Methods]A total of 268 patients with oral lichen planus confirmedby pathological examination were randomly divided into observation ( n = 134) and control ( n = 134) groups by number randommethod .Observation group were divided into subgroup A (erosion type ,n = 66) and subgroup B (non‐erosion type ,n =68) according to the results of pathological examination .And control group were also divided into subgroups C (erosion type , n = 65) and D (non‐erosion type ,n = 69) according to the results of pathological examination .The control group received 40mg triamcinolone acetonide and 2 mL 2% lidocaine injection in lesion base .On the basis of control group ,observation grouphad 1 mL BCG polysaccharide and nucleic acid injection in lesion base .The efficacies ,serum levels of inflammatory factors ,recurrenceand occurrence of adverse reactions of two groups were statistically analyzed .[Results]The rates of efficacy and totalefficacy were 58 .21% and 58 .21% in observation group versus 40 .30% and 84 .33% in control group ( P 0 .05) .The serum levels of interleukin‐6 (IL‐6) ,tumor necrosis factor‐alpha (TNF‐α) and other inflammatory factor levels before andafter treatment of group A and group B and serum IL‐6 and TNF‐α and other inflammatory factor levels before and after treatmentof group C and group D had no statistical significant difference ( P > 0 .05) .Compared with group A and group B ,serumlevels of group C were higher after treatment with 1 week ,3 weeks and 6 weeks .And the serum level of group D were alsohigher during the same period ( P < 0 .05) .Recurrence rates 1 month ,3 months ,6 months after treatment of group A werelower than those .And recurrence rates 1 month ,3 months ,6 months after treatment in group B were also lower than those ingroup D ( P < 0 .05) .[Conclusion]Local injection of triamcinolone acetonide ,BCG polysaccharide and nucleic acid injection ismarkedly efficacious for oral lichen planus .And it can effectively anti‐inflammatory ,prevent postoperative recurrence without ahigher incidence of adverse reactions .It is recommended for patients without erosive oral lichen planus .