作者通过5个Werner综合征(成年早老征)患者的29个细胞株的研究,发现1,538个中期相中92%带有异常结构重排的假二倍体的克隆,称为混杂易位嵌合体。这是Werner综合征培养的皮肤成纤维细胞的特征,其他早老样综合征的皮肤成纤维细胞中没有这种畸变。这个克隆是稳定的,产生在细胞培养的全部过程中。在三个实验室中,在用四种带有多种胎牛血清的培养基建立并 The authors studied 29 cell lines from 5 patients with Werner syndrome (adult prematurity) and found that 92% of the 1,538 metaphases with aberrant diploid clones with abnormal structural rearrangements were referred to as miscible translocation chimeras. . This is a characteristic of skin fibroblasts cultured in Werner syndrome, which is not present in other skin-fibroblasts of the presbyopic syndrome. This clone is stable and is produced throughout the cell culture. In three laboratories, they were established using four mediums with multiple fetal bovine serum