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目的观察红花注射液联合康复治疗对老年脑梗死患者的临床疗效。方法 160例老年脑梗死患者随机分为对照组及试验组,各80例。2组患者均给予常规治疗及康复治疗,试验组在此基础上加用红花注射液,每次20 mg,每天1次。2组治疗均持续28 d。比较2组患者的治疗有效率、血流动力学变化、超敏C-反应蛋白(hsCRP)、血管内皮生长因子(VEGF)以及转化生长因子-β1(TGF-β1)水平。结果试验组的治疗有效率显著高于对照组(P<0.05);2组患者血流动力学参数均优于治疗前,且试验组较对照组更优(P<0.05);治疗后,血清hsCRP水平低于对照组,VEGF以及TGF-β1水平高于对照组(P<0.05)。结论红花注射液联合康复治疗对老年脑梗死患者的疗效显著,可改善神经功能,并能显著降低患者血清hsCRP水平、提高VEGF及TGF-β1水平。
Objective To observe the clinical effects of safflower injection combined with rehabilitation on elderly patients with cerebral infarction. Methods 160 elderly patients with cerebral infarction were randomly divided into control group and experimental group, 80 cases each. The patients in both groups were given conventional treatment and rehabilitation treatment. On the basis of this, safflower injection was added to the experimental group at 20 mg once daily. Both groups continued for 28 days. The treatment efficiency, hemodynamic changes, hsCRP, VEGF and TGF-β1 were compared between the two groups. Results The therapeutic efficiency of the experimental group was significantly higher than that of the control group (P <0.05). The hemodynamic parameters of the two groups were better than those before treatment, and the experimental group was better than the control group (P <0.05) The hsCRP level was lower than that of the control group, VEGF and TGF-β1 levels were higher than the control group (P <0.05). Conclusion The combination of safflower injection and rehabilitation therapy can significantly improve the neurological function, reduce the serum hsCRP level and increase the levels of VEGF and TGF-β1 in elderly patients with cerebral infarction.