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目的探讨非小细胞肺癌(NSCLC)表皮生长因子受体(EGFR)基因突变情况及其与临床病理的关系。方法选取我院2010年1月至2014年1月收集的159份非小细胞肺癌手术切除标本为研究对象,利用基因测序方法检测标本中的EGFR基因突变情况,并分析其与临床病理的关系。结果 159例样本中,EGFR基因突变检出率为12.6%(20/159),突变主要集中在19号外显子的缺失和21号外显子的点突变。女性患者基因突变检出率明显高于男性患者(P﹤0.01)。腺癌及细支气管肺泡癌患者基因突变检出率明显高于其他组织学分型(P﹤0.01)。高分化患者基因突变检出率高于中-低分化检出率(P<0.05)。EGFR基因突变与年龄及淋巴结转移与否无关(P>0.05)。结论非小细胞肺癌患者EGFR基因突变与性别、组织学分型及分化程度密切相关。
Objective To investigate the relationship between epidermal growth factor receptor (EGFR) gene mutation and clinicopathological features in non-small cell lung cancer (NSCLC). Methods A total of 159 non-small cell lung cancer resected specimens from January 2010 to January 2014 in our hospital were selected as the research objects. The mutation of EGFR gene was detected by gene sequencing and its relationship with clinical pathology was analyzed. Results In 159 samples, the detection rate of EGFR gene mutation was 12.6% (20/159). The mutations mainly focused on the deletion of exon 19 and the point mutation of exon 21. Female patients with gene mutation detection rate was significantly higher than the male patients (P <0.01). The detection rate of gene mutations in patients with adenocarcinoma and bronchioloalveolar carcinoma was significantly higher than that in other histological types (P <0.01). The detection rate of gene mutation in well-differentiated patients was higher than that in moderate-poor differentiation (P <0.05). EGFR gene mutation had no relation with age and lymph node metastasis (P> 0.05). Conclusion EGFR gene mutations in patients with non-small cell lung cancer are closely related to sex, histological type and differentiation.