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目的探讨血清基质金属蛋白酶9(MMP-9)、血管内皮细胞生长因子(VEGF)与T2DM早期下肢血管病变的关系。方法应用ELISA对20名正常人(NC),30例T2DM无下肢血管病变(PVD)者(T2DM组),34例T2DM合并PVD者(T2DM+PVD组)血清MMP-9、VEGF水平进行测定。结果 NC组、T2DM组、T2DM+PVD组血清MMP-9[(201.34±77.09)、(281.46±112.99)、(349.12±123.76)μg/L]水平逐渐增高,差异有统计学意义(P<0.05);各组VEGF[(268.90±131.37)、(354.32±130.47)、(458.95±139.96)pg/ml]水平也依次增高,差异也有统计学意义(P<0.05)。结论 T2DM合并PVD患者血清MMP-9、VEGF水平显著增加,且两者高度正相关,提示其可能协同参与PVD的发生、发展。
Objective To investigate the relationship between serum matrix metalloproteinase 9 (MMP-9), vascular endothelial growth factor (VEGF) and vascular dysfunction in early stage of T2DM. Methods The levels of serum MMP-9 and VEGF in 20 normal subjects (NC), 30 T2DM patients without T2DM (T2DM group) and 34 T2DM patients with PVD (T2DM + PVD) group were determined by ELISA. Results The levels of serum MMP-9 [(201.34 ± 77.09), (281.46 ± 112.99), (349.12 ± 123.76) μg / L] in NC group, T2DM group and T2DM + PVD group were significantly increased ). The levels of VEGF [(268.90 ± 131.37), (354.32 ± 130.47), (458.95 ± 139.96) pg / ml] in each group also increased in turn, with statistical significance (P <0.05). Conclusion Serum levels of MMP-9 and VEGF are significantly increased in patients with T2DM complicated with PVD, and the two are highly correlated, suggesting that they may be involved in the development and progression of PVD.