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目的探讨氟康唑注射液治疗外耳道真菌病的临床治疗效果。方法选取我院2007年6月至2010年6月外耳道真菌病患者80例,将以上患者随机分为两组,观察组和对照组。两组患者在应用试验药物之前,均先清除大部分分泌物痂皮,用双氧水清洗外耳道,如果不能耐受双氧水,改为5%碳酸氢钠冲洗,而后勇棉签擦拭干。观察组患者给予0.2%氟康唑注射液,灌满外耳道,并保留20min后倾倒患儿中的药液。对照组患者采用制霉菌素片50万单位,研磨成粉末,采用洗耳球连接塑料管,把药粉喷入患耳中,2次/d。两组患者均连续治疗14d。结果观察组有效率为85.0%,对照组有效率为65.0%,两组有效率比较,差异有统计学意义(P<0.05)。结论氟康唑注射液治疗外耳道真菌病操作简单,能够有效杀灭真菌,临床效果显著,值得借鉴。
Objective To investigate the clinical efficacy of fluconazole injection in the treatment of external auditory canal fungopathy. Methods Eighty patients with external auditory canal fungal diseases were selected from June 2007 to June 2010 in our hospital. The above patients were randomly divided into two groups: observation group and control group. Two groups of patients before the application of experimental drugs, are the first to remove most of the secretions crust, with hydrogen peroxide cleaning the external auditory meatus, if not resistant to hydrogen peroxide, to 5% sodium bicarbonate rinse, then Yong cotton swab and wipe dry. Patients in the observation group were given 0.2% fluconazole injection, and the external auditory canal was filled. The patients in the observation group were allowed to pour liquid medicine in the children after 20 minutes. Control group of patients with nystatin tablets 500,000 units, ground into powder, the use of ear wash the ball connected to the plastic tube, the powder spray into the affected ear, 2 times / d. Two groups of patients were treated for 14 days. Results The effective rate was 85.0% in the observation group and 65.0% in the control group, and the difference was statistically significant (P <0.05). Conclusions Fluconazole injection is a simple, safe and effective method for the treatment of fungal diseases of external auditory canal. The clinical effect is significant and worth learning from.