测定了23例小儿服卡马西平(CBZ)达稳态浓度后血清及脑脊液中CBZ水平,并同时测定了8例儿童的唾液CBZ浓度。结果全组患儿血清CBZ浓度平均为7.7±2.5mg/L(3.1～12.7mg/L),脑脊液浓度平均是1.4±0.7mg/L(0.5～3.4mg/L),脑脊液浓度为血清浓度18±3％,二者呈相关关系,r=0.91。8例儿童唾液CBZ平均浓度为2.0±0.9mg/L(1.0～3.6mg/L),唾液浓度为血清浓度17±4％,二者间r=0.96。提示CBZ在脑脊液及唾液中的分布相似。 The levels of CBZ in serum and cerebrospinal fluid of 23 children with carbamazepine (CBZ) up to their steady-state concentrations were determined, and the concentrations of saliva CBZ in 8 children were measured simultaneously. Results The mean CBZ concentrations of all patients were 7.7 ± 2.5 mg / L (3.1-12.7 mg / L), and the mean CSF concentrations were 1.4 ± 0.7 mg / L (0.5-3.4 mg / L). The CSF concentration was 18 ± 3% respectively, r = 0.91. The average concentration of saliva CBZ in children was 2.0 ± 0.9 mg / L (1.0-3.6 mg / L) and the saliva concentration was 17 ± 4% r = 0.96. Tip CBZ distribution in the cerebrospinal fluid and saliva similar.