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新生儿溶血病（HDN）与新生儿同种免 疫性血小板减少性紫癜（NAIT）具有相同的 发病机理。基于静脉注射丙种球蛋白（IVIG） 能有效地防治NAIT,人们设想对新生儿溶血 病患儿可用大剂量IVIG来减轻溶血,降低胆 红素水平从而减少换血次数,降低发生胆红 素脑病的危险性。近年来的研究表明:孕妇、 胎儿及新生儿应用大剂量IVIG均能有效地 预防和治疗新生溶血病。 一、IVIG防治新生儿溶血病的机制 IVIG是从大量供体（至少1000名供血者）血浆中分离出的人血免疫球蛋白,含有90％以上完整的IgG及IgC亚类（1）,它具有免
Neonatal hemolytic disease (HDN) has the same pathogenesis as neonatal alloimmune thrombocytopenic purpura (NAIT). Based on the intravenous administration of gamma globulin (IVIG) can effectively prevent and treat NAIT, it is envisaged that neonatal hemolytic disease can be used in large doses of IVIG to reduce hemolysis, reduce the level of bilirubin thereby reducing the frequency of blood transfusions and reduce the risk of bilirubin encephalopathy Sex. In recent years, studies have shown that: pregnant women, fetuses and newborns using large doses of IVIG can effectively prevent and treat neuhemolysis. I. The Mechanism of IVIG in Prevention and Treatment of Neonatal Hemolytic Disease IVIG is a human immunoglobulin isolated from the plasma of a large number of donors (at least 1000 donors) and contains over 90% complete IgG and IgC subclasses (1) With free