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目的探讨血清微小RNA-222-3p(mi R-222-3p)在甲状腺乳头状癌(papillary thyroid carcinoma,PTC)中的表达及其临床意义。方法提取121例PTC及甲状腺良性疾病患者血清中的总RNA,采用q RT-PCR方法检测mi R-222-3p的表达情况,分析其与PTC临床病理特征的关系,并探讨其对PTC的临床诊断价值。结果血清mi R-222-3p在PTC患者中的中位表达水平显著高于良性对照组(2.2188 vs0.7022,P<0.05)。血清mi R-222-3p的表达水平与PTC的肿瘤最大径、双侧累及、病灶数量及淋巴结转移状况等密切相关(P均<0.05),但与性别、年龄、被膜侵犯及TNM分期等无关(P均>0.05)。ROC曲线分析显示,mi R-222-3p诊断PTC的AUC为0.717,灵敏度为79.75%,特异性为61.90%。结论血清mi R-222-3p在PTC患者中高表达,其表达水平能反映PTC的进展情况,并对PTC的临床诊断具有一定价值。
Objective To investigate the expression of mi R-222-3p in papillary thyroid carcinoma (PTC) and its clinical significance. Methods The total RNA was extracted from 121 patients with PTC and thyroid benign disease, and the expression of mi R-222-3p was detected by q RT-PCR. The relationship between the expression of mi R-222-3p and the clinicopathological features of PTC was analyzed. Diagnostic value. Results The median expression level of mi R-222-3p in PTC patients was significantly higher than that in the benign control group (2.2188 vs 0.7022, P <0.05). The expression level of R-222-3p in serum mi was closely related to the maximum diameter of tumor, bilateral involvement, the number of lesions and the status of lymph node metastasis (all P <0.05), but not with gender, age, invasion of membrane and TNM stage (P> 0.05). ROC curve analysis showed that the AUC of mi R-222-3p for diagnosis of PTC was 0.717, the sensitivity was 79.75% and the specificity was 61.90%. Conclusions Serum mi R-222-3p is overexpressed in patients with PTC. The expression of mi R-222-3p can reflect the progress of PTC and has some value in the clinical diagnosis of PTC.