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目的应用MR扩散加权成像(diffusion weighted imaging,DWI)技术评价兔肝癌化疗栓塞疗效。材料与方法首先建立兔VX2肝癌模型,采用Seldinger’s法经股动脉插管行选择性肝动脉造影成功后,行肝动脉化疗栓塞术(TACE),治疗前后行MR DWI,记录表观扩散系数(apparent diffusion coefficient,ADC)值。结果 DWI图像质量随b值增加而明显下降。整个肿瘤ADC值TACE术前为(1.48±0.36)×10 s/mm2,TACE术后为(1.78±0.15)×10 s/mm2,两者差异有统计学意义(t=2.885,P<0.05)。结论 MR DWI作为无创性检查方法,可以用于评价肝癌化疗栓塞疗效。
Objective To evaluate the efficacy of chemoembolization in rabbit liver cancer with diffusion weighted imaging (DWI). Materials and Methods: Rabbit VX2 liver cancer model was established. Seldinger’s method was used to select hepatic arterial chemoembolization (TACE) via femoral artery cannulation. MR DWI was performed before and after treatment. The apparent diffusion coefficient (apparent diffusion coefficient) was recorded diffusion coefficient, ADC) value. Results DWI image quality decreased significantly with increasing b value. The ADC value of the entire tumor was (1.48 ± 0.36) × 10 s / mm2 before TACE and (1.78 ± 0.15) × 10 s / mm2 after TACE, respectively (t = 2.885, P <0.05) . Conclusion MR DWI as a noninvasive method can be used to evaluate the efficacy of chemoembolization for hepatocellular carcinoma.