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根据发现青少年胆囊结石病人有胆囊管解剖异常现象，设计了动物兔胆囊管不全梗阻可形成胆囊结石的假说。取健康家兔２４只，雌雄不限，体重２．５ｋｇ～３．０ｋｇ，在无菌条件下行剖腹术，随机分实验组（胆囊管不全结扎１７只）和对照组（假手术７只）。成石标准以肉眼可见颗粒状或团块状结石或褐色糊状胆泥为准，并经Ｂ超、手术和病理证实。实验组成石率为６４．７％（１１／１７），对照组为１４．３％（１／７），经χ２检验，Ｐ＜０．０２５。实验表明，兔胆囊管不全梗阻与胆囊结石形成间存在着因果关系。
According to the discovery of gallbladder stones in young patients with abnormal anatomy of the cystic duct, the design of animal rabbit cystic duct insufficiency obstruction can form gallstone hypothesis. Twenty-four healthy rabbits were randomly divided into male and female, weighing 2.5kg to 3.0kg. The rabbits were randomly divided into experimental group (17 with cystic duct insufficiency) and control group (7 with sham operation) under laparotomy. Stone into the standard to the naked eye can be seen granular or lumpy stones or brown paste-like mud, subject to B-ultrasound, surgery and pathology confirmed. The rate of stone formation was 64.7% (11/17) in the control group and 14.3% (1/7) in the control group, P <0.025 by χ2 test. Experiments show that there is a causal relationship between cystic duct insufficiency and gallstone formation in rabbits.