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既往很多研究已经证实,维生素D(VitD)的缺乏与呼吸道感染之间有着内在的联系。而且许多人认为补充VitD可以作为预防呼吸道感染的手段之一。研究证实,VitD具有多种与儿童呼吸道感染相关的免疫调节特性。VitD的缺乏可以引起儿童多种呼吸道感染,包括结核病、反复发作的中耳炎、严重的支气管炎等。而VitD与其他呼吸道感染(包括咽扁桃体炎、社区获得性肺炎等)的关系需要进一步加以证实。如果机体摄入或合成VitD不足可能导致呼吸道感染的反复发生,并影响其转归,但对于补充VitD的时机与方式仍无确切结论。保持VitD充足的状态可以对部分儿童的呼吸道感染起到积极的预防作用。但是给予的补充剂量有待明确。本文就有关儿童呼吸道感染与VitD关系证据作一综述。
Many previous studies have confirmed that the lack of vitamin D (VitD) and respiratory infections are intrinsically linked. And many people think vitamin Vit supplementation can be used as a means of preventing respiratory infections. Studies confirm that VitD has a variety of immunomodulatory properties associated with childhood respiratory infections. The lack of VitD can cause multiple respiratory infections in children, including tuberculosis, recurrent otitis media, severe bronchitis and so on. The relationship between VitD and other respiratory infections (including pharyngitis tonsillitis, community-acquired pneumonia, etc.) needs to be further confirmed. If the intake of body or lack of synthesis of VitD may lead to recurrent respiratory infections and affect their outcome, but the timing and manner of VitD supplementation is still not conclusive. Maintaining adequate VitD status can have a positive preventive effect on some children’s respiratory infections. However, the amount of supplementation to be given remains to be determined. This article reviews the evidence of the relationship between childhood respiratory infection and VitD.