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曾报道粘附于粘膜的棒状制剂治疗宫颈癌可达缓释目的。含博莱霉素(BLM)30mg的药棒每周给药2次,疗效良好,而每周给药 1次,药物释放不能保持有效浓度,所以疗效不理想。本文研制一种新的双层药棒,使药物在一周内缓慢释放。制备方法棒的核心是将羟丙基纤维素(HPC)和聚羧乙烯(CP)混合粉末(3∶1)3 g,在400kg/cm~2压力下经一特制模具压制2分钟而成,长40 mm,直径2 mm、再在棒的外面,用200kg/cm~2压力,压上外层,使直径
It has been reported sticking to the mucous membrane of the rod preparation for the treatment of cervical cancer remission purposes. The drug rod containing bleomycin (BLM) 30mg was administered twice a week with good curative effect. However, once a week, the drug release could not maintain the effective concentration, so the curative effect was not satisfactory. This article developed a new double-stick, the drug released slowly within a week. Preparation Method The core of the bar is that 3 g of hydroxypropyl cellulose (HPC) and polyvinyl chloride (CP) mixed powder (3: 1) is pressed for 2 minutes under a pressure of 400 kg / cm ~ Length 40 mm, diameter 2 mm, and then in the stick outside, with 200kg / cm ~ 2 pressure, pressure on the outer layer, the diameter