邱卓嶷等人首先把毛冬青甲素应用于严重心力衰竭患者,采用随机双盲,特别是自身交叉试验方法在同一患者群体中比较一种新药和另一已知有效药物的疗效,比在两个不同患者群体中作平行试验更有说服力。通过对18例符合临床和血液动力学选择标准的心衰患者,随机分先用多巴酚丁胺,后用毛冬青甲素或先用毛冬青甲素,后用多巴酚丁胺两 Qiu Zhuo-chuen, who first applied hamazone to patients with severe heart failure, compared the efficacy of a new drug with another known effective drug in a population of patients using a randomized double-blind, in particular crossover test, Parallel testing in two different patient groups is more convincing. 18 patients with heart failure who met clinical and hemodynamic criteria were randomized to receive either dobutamine, followed by havonidin or halotombin, followed by dobutamine two