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目的:观察奥美拉唑肠溶片(阿斯利康)联合莫沙必利片(鲁南贝特)治疗老年反流性食管炎的疗效。方法:将反流性食管炎患者47例随机分为两组,观察组24例采用奥美拉唑联合莫沙必利治疗4周、8周;对照组23例只采用奥美拉唑治疗4周、8周,之后两组均改用半量维持治疗半年,间歇治疗1年,随访观察,对其4周临床症状的改善及内镜上消化道黏膜病变的发展变化进行分析。结果:治疗4周、8周后,急性期观察组在临床症状改善及内镜上消化道黏膜病变发展的控制上显著优于对照组(P<0.05);1年随访观察组反流性食管炎的复发率显著低于对照组(P<0.05)。结论:奥美拉唑联合莫沙必利治疗老年反流性食管炎的临床疗效肯定。
Objective: To observe the efficacy of omeprazole enteric-coated tablets (AstraZeneca) combined with mosapride (lumbar puncture) in the treatment of senile reflux esophagitis. Methods: Forty-seven patients with reflux esophagitis were randomly divided into two groups. 24 cases in observation group were treated with omeprazole combined with mosapride for 4 weeks and 8 weeks, and 23 cases in control group were treated with omeprazole only Week and 8 weeks. After that, the two groups were switched to half-dose maintenance therapy for six months and intermittent therapy for one year. Follow-up observation was performed to evaluate the clinical symptoms and endoscopic gastrointestinal mucosal lesions. Results: After 4 weeks and 8 weeks of treatment, the acute observation group was significantly better than the control group in improving the clinical symptoms and controlling the development of gastrointestinal mucosal lesions (P <0.05). In the 1-year follow-up observation group, the reflux esophagus The recurrence rate of inflammation was significantly lower than that of the control group (P <0.05). Conclusion: The clinical efficacy of omeprazole combined with mosapride in the treatment of senile reflux esophagitis is sure.