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调节性T细胞(Treg)能有效地抑制免疫应答,与自身免疫性疾病、肿瘤等多种疾病的发生密切相关。Toll样受体4(TLR4)识别细菌的脂多糖(LPS)后诱导产生炎性因子和炎症反应,也能介导疾病的发生发展。最新研究发现其在出血性休克和复苏后的多器官功能障碍[1]、动脉粥样硬化[2]及癌症[3]等多种疾病中扮演重要角色。越来越多的研究表明TLR4能调节Treg的抑制功能,因此,有望为疾病的治疗提供新的靶点。目前TLR4、Treg及其相互影响和作用机制已
Regulatory T cells (Tregs) can effectively suppress the immune response, and autoimmune diseases, tumors and other diseases are closely related. Toll-like receptor 4 (TLR4) recognizes bacterial lipopolysaccharide (LPS) and then induces the production of inflammatory cytokines and inflammatory responses. It also mediates the development of the disease. Recent research has found it plays an important role in multiple diseases such as multiple organ dysfunction after hemorrhagic shock and resuscitation [1], atherosclerosis [2] and cancer [3]. More and more studies have shown that TLR4 can regulate the suppressive function of Treg, so it is expected to provide a new target for the treatment of diseases. Currently TLR4, Treg and its interaction and mechanism of action has been