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驱钩虫新药三苯双脒为阿米登太的类似物。单剂25mg/kg对大鼠巴西日本圆线虫和犬钩虫的驱虫有效率分别为99.3％和91.9％。驱尽仓鼠体内美洲钩虫的剂量为顿服150mg/kg。三苯双脒一次口服对大、小鼠的急性LD_(50)分别为2001±79mg/kg和950±207mg/kg。小鼠一次腹腔注射急性LD_(50)为277±27mg/kg。大鼠和犬每天分别口服三苯双脒125～750mg/kg(治愈剂量的5～30倍)和30～120mg/kg(相当拟推荐临床治疗剂量的5～20倍)连续14d时,对血液及肝、肾功能均无明显影响;对肝、胃、小肠及肾等脏器仅有轻微可逆性病理损害。犬口服大剂量的兰苯双脒可发生流涎、呕吐和阵发性抽搐,重者可因呼吸停止而死亡。
The new hookworm drug tribendimidine is an analog of amiodarone. A single dose of 25mg / kg on rats Brazil round worm and canine hookworm deworming efficiency were 99.3% and 91.9%. Exhaust Hamster body dose of American hookworm Dayton clothing 150mg / kg. The acute LD_ (50) dose of triphenylbutyramide in large and large mice was 2001 ± 79 mg / kg and 950 ± 207 mg / kg, respectively. The intraperitoneal injection of acute LD 50 in mice was 277 ± 27 mg / kg. Rats and dogs were orally administered with tribendimidine 125 ~ 750mg / kg (5 ~ 30 times as much as cure) and 30 ~ 120mg / kg (5 ~ 20 times as much as the recommended clinical treatment) And liver and kidney function had no significant effect on the liver, stomach, small intestine and kidney and other organs only slight reversible pathological damage. Canine oral large doses of albendazole can occur salivation, vomiting and paroxysmal convulsions, severe cases of death due to respiratory arrest.