盆底组织胶原降解增加引起盆底组织支持力减弱是压力性尿失禁的重要发病机制。基质金属蛋白酶(MMP)作为最重要的胶原降解酶,它的表达增加,活性增高及与其组织抑制剂比例的改变可能是盆底胶原降解增加的主要原因,对它在压力性尿失禁发病中作用的研究,为进一步阐明压力性尿失禁的发病机制,寻找更好的预防和治疗方法提供了新的思路。 Pelvic floor tissue collagen degradation caused by pelvic floor tissue support weakening stress urinary incontinence is an important pathogenesis. As the most important collagenolytic enzyme, matrix metalloproteinases (MMPs), whose expression is increased, the activity is increased and the ratio of them to its tissue inhibitor may be the main reason for the increase of pelvic floor collagen degradation, and its role in stress urinary incontinence Research, to further clarify the pathogenesis of stress urinary incontinence, looking for better prevention and treatment provides a new way of thinking.