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脂蛋白(a)[Lp(a)]是与低密度脂蛋白(LDL)极为相似的蛋白质,已被认为可作为一种相对独立的蛋白,能与纤溶酶原竞争结合受体,在功能上具有影响纤维蛋白溶解的特性。在2型糖尿病肾病患者中,血清Lp(a)的生成增多,分解减少,造成体内Lp(a)水平升高,并且通过多种机制影响机体的凝血纤溶系统,打破凝血纤溶的平衡,造成体内的高凝状态以及继发性纤溶活性的增强,从而引起糖尿病患者肾脏损害的发生发展。
Lipoprotein (a) [Lp (a)] is a very similar protein to low density lipoprotein (LDL) and has been considered as a relatively independent protein that competes with plasminogen for binding to receptors, Has a characteristic that affects fibrinolysis. In patients with type 2 diabetic nephropathy, serum Lp (a) production increases, decomposition decreases, resulting in elevated levels of Lp (a) in vivo, and through a variety of mechanisms affecting the body’s coagulation and fibrinolysis system, to break the balance of coagulation and fibrinolysis, Resulting in the body hypercoagulable state and secondary fibrinolytic activity increased, resulting in the development of kidney damage in diabetic patients.