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32例控制欠佳的Ⅱ型糖尿病病人保持降糖药、饮食和运动不变 ,加静脉滴注葛根素治疗前后行胰岛素耐量试验 ,算Kitt值 ,测血粘度和红细胞变形指数 (DImax) ,聚集指数 (ALmax)及口服葡萄糖耐量 (OGTT) ,胰岛素释放试验。结果 :用葛根素后Kitt值上升 ,DImax提高 (P <0 0 1 ) ;OGTT、血粘度血脂改善 (P <0 0 5～ 0 0 1 ) ,而胰岛素无变化。结论 :葛根素可提高Ⅱ型糖尿病人胰岛素敏感性。其机制可能是通过改善红细胞膜弹性和血流状况而提高胰岛素活性。
32 cases of type 2 diabetes patients with poor control maintain hypoglycemic agents, diet and exercise unchanged, plus intravenous infusion of puerarin insulin tolerance test before and after treatment, calculated Kitt value, blood viscosity and erythrocyte deformability index (DImax), aggregation Index (ALmax) and oral glucose tolerance (OGTT), insulin release test. Results: After treated with puerarin, Kitt increased, DImax increased (P <0.01); OGTT, blood viscosity improved (P <0.05 ~ 0.01), while insulin did not change. Conclusion: Puerarin can improve insulin sensitivity in type 2 diabetic patients. Its mechanism may be through the improvement of red blood cell membrane elasticity and blood flow conditions and improve insulin activity.