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目的探讨可溶性髓样细胞触发受体-1(soluble triggering receptor expressed on myeloid cells-1,sTREM-1)对脓毒血症的早期诊断价值。方法 81例全身炎症反应综合征患者,根据脓毒血症诊断标准分为脓毒血症组35例与SIRS组46例,选择体检健康者30名为对照组,检测3组血清sTREM-1、降钙素原(procalcitonin,PCT)、C反应蛋白(C reactive protein,CRP)水平。结果脓毒血症组与SIRS组患者血清sTREM-1,PCT及CRP水平均高于对照组(P<0.05);脓毒血症组血清sTREM-1与PCT水平高于SIRS组(P<0.05),CRP水平与SIRS组比较差异无统计学意义(P>0.05)。结论血清sTREM-1是脓毒血症早期诊断的辅助指标,其灵敏度和特异性高于PCT和CRP。
Objective To investigate the early diagnostic value of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in sepsis. Methods Seventy-one patients with systemic inflammatory response syndrome were divided into 35 cases of sepsis and 46 cases of SIRS according to the diagnostic criteria of sepsis. Thirty healthy subjects were selected as the control group. Serum sTREM-1, Procalcitonin (PCT) and C reactive protein (CRP) were measured. Results The levels of sTREM-1, PCT and CRP in sepsis group and SIRS group were significantly higher than those in control group (P <0.05). The levels of sTREM-1 and PCT in sepsis group were higher than those in SIRS group (P <0.05) ), There was no significant difference between CRP and SIRS (P> 0.05). Conclusion Serum sTREM-1 is an adjunct to early diagnosis of sepsis with higher sensitivity and specificity than PCT and CRP.