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目的探讨肝肠钙粘连蛋白(LI-cadherin)在肝细胞肝癌中的表达水平及其临床意义。方法应用免疫组织化学链霉素亲生物素-过氧化酶标记法(S-P)检测LI-cadherin蛋白在62例肝癌组织、30例癌旁肝组织中的表达水平,并分析其与临床病理学特征之间的关系。结果肝癌组织中LI-cadherin蛋白阳性表达率为64.5%(40/62),在癌旁组织中其阳性表达率为26.7%(8/30),LI-cadherin蛋白的过表达与肝癌细胞的分化程度、癌栓的形成及淋巴结转移等临床病理因素有关(P<0.05)。结论 LI-cadherin在肝癌细胞的发生、发展过程中起重要作用。LI-cadherin蛋白的过表达与肝癌细胞的门静脉癌栓、淋巴结转移有关,提示其在肝癌的增殖、侵袭和迁移中发挥重要的作用。
Objective To investigate the expression of LI-cadherin in hepatocellular carcinoma and its clinical significance. Methods Immunohistochemical streptavidin-biotin-peroxidase (SP) method was used to detect the expression of LI-cadherin protein in 62 cases of hepatocellular carcinoma and 30 cases of paracancer liver tissues, and to analyze its relationship with clinicopathological features The relationship between. Results The positive expression rate of LI-cadherin protein in hepatocellular carcinoma tissues was 64.5% (40/62), and the positive expression rate of LI-cadherin protein in cancer tissues was 26.7% (8/30). The overexpression of LI-cadherin protein and the differentiation of hepatoma cells Degree, the formation of tumor thrombus and lymph node metastasis and other clinicopathological factors (P <0.05). Conclusion LI-cadherin plays an important role in the occurrence and development of hepatoma cells. The overexpression of LI-cadherin protein is associated with portal vein tumor thrombus and lymph node metastasis in hepatocellular carcinoma cells, suggesting that it plays an important role in the proliferation, invasion and migration of hepatocellular carcinoma.