论文部分内容阅读
目的探讨用PET/CT制定生物靶区行三维适形调强放疗的可行性,并判断放疗疗效。方法用Siemens Biograph Sensation 16型PET/CT仪和Varian clinical 600c和Nomos Peacock系统放疗计划系统(TPS)进行适形调强放疗技术设计研究。64例肿瘤患者,根据不同放疗部位制作放疗体模,应用激光线和自行制作的3个金属点源进行定位,将采集的PET/CT图像通过光盘存储,送至TPS进行治疗计划制定,由放疗物理师和医师根据PET和CT资料应用计划系统的图像融合软件,使图像达到融合标准后制定放疗计划靶区。治疗期间详细记录患者症状及早期放射反应,放疗结束后3个月再进行近期疗效评价。结果建立了PET/CT和Peacock适形调强放疗系统实用融合图像方法学;64例受试患者中25例(39．0%)治疗计划通过PET/CT显像发生了改变,其中20例计划靶区体积(PTV)范围增加(20/64例,31．2%),5例(5/64例,7．8%)PTV范围减小;64例患者经过PET/CT技术定位放射治疗后均取得良好疗效。结论建立在适形调强放疗系统的PET/CT融合图像方法学是完成治疗的首要问题,该方法的应用将提高制定生物靶区体积的精确性。
Objective To explore the feasibility of using PET/CT to establish three-dimensional conformal intensity modulated radiotherapy in the biological target area, and to determine the efficacy of radiotherapy. Methods The technique of conformal intensity modulated radiation therapy was studied with Siemens Biograph Sensation 16 PET/CT and Varian clinical 600c and Nomos Peacock system radiotherapy planning system (TPS). In 64 cases of cancer patients, radiotherapy phantoms were made according to different radiotherapy sites, laser lines and three metal point sources made by themselves were used for positioning. The collected PET/CT images were stored on optical disks and sent to TPS for treatment planning. Radiotherapy was performed. Physicists and Physicians use image fusion software of the planning system based on the PET and CT data to enable the image to reach the fusion criteria and develop the radiotherapy plan target area. During the treatment period, the patient’s symptoms and early radiation response were recorded in detail, and short-term efficacy evaluation was performed 3 months after the end of radiotherapy. Results A practical fusion image methodology for the PET/CT and Peacock conformal intensity modulated radiotherapy systems was established; 25 (39.0%) of the 64 subjects had their treatment plans changed by PET/CT imaging, of which 20 were planned. The target volume volume (PTV) range increased (20/64 cases, 31.2%), and the PTV range of 5 cases (5/64 cases, 7.8%) decreased; 64 patients after PET/CT positioning therapy Have achieved good results. Conclusion The PET/CT fused image methodology established in the conformal intensity modulated radiotherapy system is the most important issue to complete the treatment. The application of this method will improve the accuracy of the formulation of the biological target volume.