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目的探讨沙美特罗替卡松治疗稳定型慢阻肺对肺功能及心理状态的影响。方法选择80例患者,随机分为观察组和对照组各40例,对照组使用止咳、祛痰、吸氧、抗生素预防和治疗感染、加强营养支持、加强心理干预等措施,观察组在对照组的基础上采用沙美特罗替卡松,比较治疗前后患者焦虑抑郁评分及治疗后肺功能。结果观察组治疗后焦虑和抑郁评分均显著低于治疗前,且低于治疗后的对照组,差异有统计学意义(P<0.05);治疗后观察组FEV1及FVC均显著大于对照组,且FEV1/FVC高于对照组,差异有统计学意义(P<0.05)。结论沙美特罗替卡松治疗稳定型慢阻肺患者能有效减轻患者焦虑抑郁情况,提高患者肺功能,保证治疗效果。
Objective To investigate the effects of salmeterol and fluticasone on lung function and psychological status in patients with stable COPD. Methods Eighty patients were randomly divided into observation group (40 cases) and control group (40 cases). The control group was treated with antitussive, expectorant, oxygen inhalation, antibiotic prophylaxis and treatment of infection, nutrition support and psychological intervention. Based on the use of salmeterol / fluticasone, the anxiety and depression score and the post-treatment lung function were compared before and after treatment. Results After treatment, anxiety and depression scores of the observation group were significantly lower than those before treatment and lower than those of the control group after treatment (P <0.05); after treatment, the FEV1 and FVC of the observation group were significantly greater than those of the control group FEV1 / FVC higher than the control group, the difference was statistically significant (P <0.05). Conclusion Salmeterol and ticagastrone in patients with stable chronic obstructive pulmonary disease can effectively reduce anxiety and depression in patients, improve lung function and ensure the therapeutic effect.