The superficial dorsal horn of the spinal cord, where the primary nociceptive afferent fibers terminate, contains a huge of message molecules and their receptors responsible for spinal nociception. The rapidly increasing evidence has particularly shown that glutamate and substance P are the most important transmitters and/or modulators in processing nociceptive information in the spinal cord. Recently emphasis has also been The superficial dorsal horn of the spinal cord, where the primary nociceptive afferent fibers terminate, contains a huge of message molecules and their receptors responsible for spinal nociception. The rapidly increasing evidence has particularly shown that glutamate and substance P are the most important transmitters and / or modulators in processing nociceptive information in the spinal cord