论文部分内容阅读
Six polyamides with pendant 5-fluorouracil group were synthesized by the polycondensation ofdi-p-nitrophenyl N-(5-fluorouracil-1-acetyl)glutamate with a series of polymethylene diamines.All of the new polyamides obtained are soluble in water. Their chemical structures were confirmedby ~1H NMR, UV and IR spectra as well as elemental analyses. The antitumor activity of some ofthese polyamides were tested against Ehrlich Ascites Carcinoma in mice, III_a showed an inhibitionrate of 43%.
Six polyamides with pendant 5-fluorouracil group were synthesized by the polycondensation of di-p-nitrophenyl N- (5-fluorouracil-1-acetyl) glutamate with a series of polymethylene diamines. All of the new polyamides obtained are soluble in water. Their chemical The structures were confirmed ~ 1H NMR, UV and IR spectra as well as elemental analyzes. The antitumor activity of some of the polyamides were tested against Ehrlich Ascites Carcinoma in mice, III_a showed an inhibition rate of 43%.