目的:基于“以俞调枢”理论,探讨疏肝和胃穴位埋线法对非小细胞肺癌化疗所致延迟性呕吐的临床疗效。方法:采用前瞻性临床随机对照方法,将60例经病理学或细胞学确诊的非小细胞肺癌患者,拟行含铂两药方案化疗者,按数字随机法分为观察组和对照组。对照组给予常规止吐方案:盐酸昂丹司琼注射液8mg静注,bid,d1~d3;地塞米松注射液12mg静滴,qd,d1~d3;观察组在常规方案基础上加用疏肝和胃穴位埋线,于化疗第1天埋线。化疗1个周期后,比较两组患者化疗后d1~d6主要症状即呕吐的发生情况,次要症状即食欲不振、便秘、腹胀、乏力的发生情况,以及化疗前后生活质量的变化情况。结果:急性呕吐(d1),两组呕吐发生率无统计学差异(p>0.05);延迟性呕吐(d4~d6),观察组呕吐发生率明显低于对照组(P<0.05),呕吐控制的有效率亦明显优于对照组(P<0.05);生活质量评估方面,观察组KPS评分和QOL评分在化疗前后无明显差异,而对照组下降较明显(P<0.05);在次要症状方面,观察组化疗相关食欲不振、便秘、腹胀、乏力等不良反应明显少于对照组(P<0.05)。结论:疏肝和胃穴位埋线法联合西医止吐方案在防治非小细胞肺癌患者高致吐风险化疗所致的延迟性呕吐方面,明显优于单纯西药止吐方案,且能改善化疗期间患者的生活质量。 OBJECTIVE: To investigate the clinical effect of Shugan and stomach acupoint catgut embedding therapy on delayed emesis induced by chemotherapy in non-small cell lung cancer based on the theory of Yu tune pivot. Methods: A prospective randomized controlled clinical trial was conducted in 60 patients with pathologically or cytologically diagnosed non-small cell lung cancer who were scheduled for chemotherapy with platinum-based regimen. The patients were divided into observation group and control group according to random number method. Control group were given conventional antiemetic solution: Ondansetron hydrochloride injection 8mg intravenous, bid, d1 ~ d3; dexamethasone injection 12mg intravenous infusion, qd, d1 ~ d3; observation group on the basis of the conventional program with sparse Catgut embedding of liver and stomach, embedding in the first day of chemotherapy. After one cycle of chemotherapy, the main symptoms of d1 ~ d6, ie the occurrence of vomiting, were compared between the two groups after chemotherapy. The secondary symptoms were the loss of appetite, constipation, abdominal distension and fatigue, and the changes of the quality of life before and after chemotherapy. Results: Acute vomiting (d1) showed no significant difference in the incidence of vomiting between the two groups (p> 0.05); vomiting (d4 ~ d6) in the observation group was significantly lower than that of the control group (p <0.05) (P <0.05). In terms of quality of life, KPS score and QOL score in the observation group had no significant difference before and after chemotherapy, but decreased significantly in the control group (P <0.05). In the secondary symptoms Aspects, adverse reactions such as loss of appetite, constipation, bloating and fatigue in the observation group were significantly less than those in the control group (P <0.05). Conclusion: Shugan and stomach acupuncture combined with western medicine antiemetic solution in the prevention and treatment of non-small cell lung cancer risk of vomiting caused by high spit-vomiting chemotherapy was significantly better than the simple western medicine antiemetic program, and can improve the patients during chemotherapy The quality of life